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Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits
2026-01-05
genetic and genomic medicine
Title + abstract only
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Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational screening technology provides a novel approach to quantifying trans-effects between gene pairs, but its integration with GWAS data remains largely unexamined. We introduce Mr. PEG, a novel framework that integrates perturbational screens, eQTL, and GWAS summary data to identify mediating genes of comp...
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