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Quantifying inflammatory resolution in human menstruation reveals disease-specific failure modes and enables a non-invasive diagnostic for endometriosis
2026-01-02
obstetrics and gynecology
Title + abstract only
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Inflammatory resolution is essential for tissue health, yet its dynamics remain difficult to study in humans. Menstruation is a recurrent, non-pathological inflammatory process that provides a natural window into inflammation and repair. We developed and validated a standardized menstrual sampling and RNA-seq workflow, analyzing more than 1,000 samples from over 300 individuals. We show that menstrual transcriptomes are dominated by two major biological confounders: heterogeneous tissue composit...
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