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Admixture mapping identifies complex trait associations with local ancestry in the All of Us Research Program
2025-12-29
genetic and genomic medicine
Title + abstract only
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Genetic studies have largely focused on homogeneous populations, limiting our understanding of the genetic architecture of complex traits in admixed individuals. The advent of diverse biobanks like the All of Us Research Program (AoU) and computationally efficient local ancestry inference (LAI) methods now enable admixture mapping (ADM) at biobank scale. Here, we used two orthogonal LAI methods (GNOMIX and FLARE) to characterize local ancestry in the entire AoU v7.1 cohort (n=230,019). We then u...
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