Colibactin produced by a honeybee symbiont defends against pathogens and shapes the gut community
Song, Y.; Powell, J. E.; Wong, J.; Liu, Y.; Aguilar Ramos, M. A.; de Jong, T.; Lariviere, P. J.; Maganti, J.; Balskus, E. P.; Moran, N. A.
Show abstract
Colibactin is a bacterial genotoxin that is linked to colorectal cancer and implicated in interbacterial competition; however, its role in natural communities remains unknown. Frischella perrara, a symbiont living only in honeybee guts, produces colibactin and causes DNA damage. Here, we found that F. perrara mono-colonization reduces bee lifespan but increases survivorship following challenge with an opportunistic pathogen. F. perrara reduces pathogen loads by causing colibactin-dependent DNA damage and prophage induction. clbS, a gene conferring protection from colibactin, is ubiquitous among bacteria restricted to bee guts but is absent from opportunistic colonizers including bee pathogens. Our findings provide evidence that colibactin functions in interbacterial competition, exerts selective pressure on community members, and confers protection against pathogens, while permitting co-evolved gut symbionts to persist.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Gut microbiota influences foraging onset without affecting division of labor and associated physiological hallmarks in honeybees 96%
- High levels of cyclic diguanylate interfere with beneficial bacterial colonization 95%
- RprR is a plant-responsive regulator of exopolysaccharide production, biofilm formation, and virulence in Ralstonia pseudosolanacearum 95%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence 96%
- Natural monobacterial environments modulate viral infection in Caenorhabditis elegans 95%
- Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy 94%
Similar papers in this journal
- Evolutionary recent dual obligatory symbiosis among adelgids indicates a transition between fungus and insect associated lifestyles 95%
- Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations 95%
- Gut microbes contribute to variation in foraging intensity in the honey bee, Apis mellifera. 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.