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Enhancing Polygenic Risk Prediction by Modeling Quantile-Specific Genetic Effects

2025-12-29 epidemiology Title + abstract only
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Polygenic risk scores (PRSs) quantify an individuals genetic susceptibility to complex traits and diseases. Conventional PRSs, which are based on linear models, perform poorly for phenotypes with skewed distributions or with genetic effects that vary across the distribution. We propose a quantile regression-based PRS (QPRS) that can capture quantile-specific genetic effects. While existing PRSs provide only a single score, QPRS models genetic influences at multiple quantiles of the phenotype, th...

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