Genomic profiling implicates candidate genes and mutagenic pathways driving lung cancer recurrence

2026-01-01 oncology Title + abstract only

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Lung cancer remains the leading cause of cancer-related deaths worldwide, with tumor recurrence a major contributor to its high mortality. The genetic and molecular mechanisms of recurrence remain poorly understood. Using whole-exome sequencing of 155 primary non-small cell lung cancers, we studied the mutational landscape and driver alterations associated with recurrence. Primary tumors that developed recurrence had higher mutational burden, including hypermutated tumors explained by mutations ...

Genomic profiling implicates candidate genes and mutagenic pathways driving lung cancer recurrence

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