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Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population

2025-12-27 genetic and genomic medicine Title + abstract only
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X chromosome-wide association studies (XWAS) have successfully identified risk loci on the X chromosome associated with Parkinsons disease (PD) susceptibility. However, only three such studies have been completed to date. Here, we present the first XWAS using an African cohort, comprising 690 PD cases and 826 controls. We applied an established XWAS workflow to perform male- and female-stratified analyses, as well as a combined meta-analysis. The male-stratified analysis identified five signific...

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