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Shared genetic architecture of brain age gap across 30 cohorts worldwide

2025-12-27 genetic and genomic medicine Title + abstract only
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Deviations from normative brain ageing trajectories are linked to a wide range of adverse health outcomes. A number of brain age prediction models have been developed, based on various neuroimaging modalities, machine learning algorithms, training samples, and age ranges. However, it remains unknown whether these models converge on a shared genetic liability, and whether capturing this shared signal could provide a more sensitive marker of brain health than any single model alone. We first condu...

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