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MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemia

2025-12-31 gastroenterology Title + abstract only
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Hereditary -tryptasemia (HT), defined by increased TPSAB1 copy number and elevated basal serum tryptase, is associated with mast cell (MC)-mediated symptoms, yet its role in gastrointestinal disease remains unclear. Because intestinal MCs express the non-IgE-dependent activation receptor MRGPRX2, we investigated whether MRGPRX2 expression is altered in individuals with HT and inflammatory bowel disease (IBD). We genotyped 854 biobanked IBD samples, performed spatial transcriptomics on descending...

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