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Decoding WNT Pathway Dysregulation in Bevacizumab-Treated Early-Onset Colorectal Cancer to Inform Precision Oncology
2025-12-23
gastroenterology
Title + abstract only
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Early-onset colorectal cancer (EOCRC) is rising most rapidly among Hispanic/Latino (H/L) populations, yet the prognostic relevance of WNT pathway alterations under contemporary therapies remains unclear. We conducted a multi-cohort analysis integrating somatic genomics with clinical and treatment annotations (including bevacizumab exposure) from public CRC datasets, stratifying by age of onset and ancestry (H/L vs. non-Hispanic White [NHW]). WNT alterations, dominated by APC, were ubiquitous, bu...
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