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Leveraging Limited Testing Data for Early Detection of Emerging Infectious Disease Outbreaks

2025-12-29 infectious diseases Title + abstract only
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Early during emerging infectious disease outbreaks, case-based surveillance is constrained by limited test availability, diagnostic delays, and low clinical suspicion. Novel pathogens that mimic symptoms of established conditions may generate detectable outbreak signals in routine testing data, as infected individuals seek testing for known conditions and test negative. We developed analytic and simulation frameworks using Poisson and negative binomial models to evaluate whether total and negati...

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