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Seasonal and Vitamin D3 mediated methylome reprogramming of peripheral immune cells and anti-viral responses

2025-12-29 epidemiology Title + abstract only
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Seasonality of inflammatory and infectious diseases is associated with several factors, including serum vitamin D fluctuations and immunological state. We longitudinally investigated peripheral blood mononuclear cell (PBMC) methylomes of healthy South African adults in summer, winter, and after high-dose winter vitamin D3 supplementation to determine whether vitamin D3 modulates seasonal epigenetic variations and whether these underpin reported seasonal transcriptional oscillations. PBMC DNA met...

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