Unraveling the Potential of Physical Activity and High-Intensity Interval Training in the Treatment of Familial Hypercholesterolemia: Impact on Cardiorespiratory Fitness, Atherosclerosis, and Underlying Mechanisms. Study protocol of the UPPA-FH Project.

2025-12-29 sports medicine Title + abstract only

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IntroductionFamilial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein -cholesterol (LDL-c) levels, increasing early cardiovascular risk. Many patients do not reach LDL-c targets despite treatment. Physical activity and exercise may help by improving cardiorespiratory fitness (CRF), reducing inflammation, and modulating metabolic pathways. This study aims 1) to cross-sectionally evaluate the association of physical activity and CRF with markers of ...

Unraveling the Potential of Physical Activity and High-Intensity Interval Training in the Treatment of Familial Hypercholesterolemia: Impact on Cardiorespiratory Fitness, Atherosclerosis, and Underlying Mechanisms. Study protocol of the UPPA-FH Project.

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