Invariant activity sequences across the mouse brain
Bimbard, C.; Harris, K. D.; Carandini, M.
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An ambition of neuroscience is to identify fundamental patterns of neural activity that are shared across the brain. Candidate patterns for such a canonical role occur in the cerebral cortex, where neurons fire in 50-100 ms sequences. Here we show that these sequences are stable over time and ubiquitous across the brain. Chronic Neuropixels recordings in mouse visual cortex revealed that each neuron was coupled to the local population with a characteristic strength and delay. Stimulus responses formed a sequence where neuronal participation depended on tuning, but delay was fixed. This sequence interacted multiplicatively with the rate code, appeared even during spontaneous activity, and remained stable for weeks. Brainwide Neuropixels recordings revealed that the sequences occur across the entire mouse brain and are synchronized across regions. These results reveal a stable scaffold for brainwide activity and suggest that the sequences support a canonical computation operating across the brain.
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