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Autoregulation of three yeast ribosomal protein genes by splicing inhibition

Granas, D.; Kesanapally, A.; White, M. A.; Stormo, G. D.

2025-12-19 molecular biology
10.64898/2025.12.19.695493 bioRxiv
Show abstract

Yeast ribosomal protein genes RPL18B, RPL28 and RPS22B are autoregulated by inhibition of splicing. This is demonstrated by inserting their introns into a chromosomal copy of GFP and observing repression upon induction of the cognate protein. In RPL18B and RPS22B, a predicted conserved secondary structure within the intron is required for regulation, while in RPL28 it is not.

Published in G3: Genes, Genomes, Genetics (predicted rank #4) · training set

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