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TASTE identifies shared proteomic effects on multiple related cancers
2025-12-29
epidemiology
Title + abstract only
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IntroductionGenome-wide association studies (GWAS) have identified hundreds of variants linked to cancers, but their downstream regulatory consequences remain poorly understood. Increasing evidence suggests that related cancers share alterations of common regulatory programs. Trans-associations of cancer risk variants mediated via molecular phenotypes, such as gene expression and protein levels, can help uncover these downstream mechanisms. Further investigation of such convergence can reveal sh...
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