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Colorectal cancer risk variants in the 11q13.4 locus are associated with variable POLD3 transcript expression which may promote DNA damage and telomere shortening in colorectal cancer cells
2025-12-27
oncology
Title + abstract only
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DNA Polymerase Delta (Pol {delta}) acts in DNA synthesis and in DNA repair, both important factors in the proliferative nature, longevity, and mutability of cancer cells. The chromosomal region containing POLD3, the third subunit of Pol {delta}, has recently been identified by genome wide-association studies as containing single nucleotide polymorphisms (SNPs) that increase the risk of colorectal cancer (CRC). Here, we have used genetic fine mapping and functional annotation tools to identify a...
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