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BMPR-II biomarkers for testing therapeutic efficacy in pulmonary arterial hypertension: The StratosPHere 1 study.
2025-12-20
respiratory medicine
Title + abstract only
View on medRxiv
Show abstract
Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease where deficiency of the TGF/BMP pathways have causal roles in hereditary and idiopathic forms. It is an attractive candidate for therapeutic intervention but there is an unmet need for clinically-relevant and practical biomarkers that can measure target engagement. A major challenge has been the inaccessibility of lung tissue in disease for molecular profiling. Here we explore the surrogate capacity of peripheral blood BMP pa...
Predicted journal destinations
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American Journal of Respiratory and Critical Care Medicine
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ERJ Open Research
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Scientific Reports
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BMJ Open Respiratory Research
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Frontiers in Immunology
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Journal of Allergy and Clinical Immunology
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PLOS ONE
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eLife
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Journal of Clinical Investigation
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EMBO Molecular Medicine
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Frontiers in Cardiovascular Medicine
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BMJ Open
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The Lancet Respiratory Medicine
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Circulation: Genomic and Precision Medicine
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Proceedings of the National Academy of Sciences
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