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GenBrain: A Generative Foundation Model of Multimodal Brain Imaging

2025-12-20 radiology and imaging Title + abstract only
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Neuroimaging faces a reproducibility crisis, where studies on small, heterogeneous datasets produce unreliable brain-wide associations and AI models that fail to generalize. To address this, we introduce GenBrain, a generative foundation model pretrained on approximately 1.2 million 3D scans from over 44,000 individuals across 34 imaging modalities to learn a population prior of brain structure and function. Crucially, GenBrain enables rapid, data-efficient adaptation, allowing any targeted stud...

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