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Single-cell analysis identifies monocyte signatures of disease activity and clinical subtypes in Behcet disease
2025-12-27
rheumatology
Title + abstract only
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ObjectivesBehcets disease (BD) is a multisystem inflammatory disorder with diverse phenotypes and incompletely defined immune mechanisms. This study aimed to map immune dysregulation in BD at high resolution, comparing active versus remission states and identifying pathways linked to clinical phenotypes. MethodsWe performed single-cell RNA sequencing on 247,028 peripheral blood mononuclear cells (PBMCs) from 34 BD patients and 12 healthy controls. Transcriptomic profiling, differential gene exp...
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