Back

Elevated Levels of IL-9 Fail to Suppress Pathogenic T helper 17 cells in Sjogrens Disease

2025-12-22 allergy and immunology Title + abstract only
View on medRxiv
Show abstract

Sjogrens disease (SjD) is a chronic autoimmune disorder characterized by inflammation of the exocrine glands, leading to dry mouth and dry eyes. This study investigates the role of interleukin-9 (IL-9) and T helper 9 (Th9) cells in the pathogenesis of SjD. We found that serum IL-9 levels were significantly elevated in SjD patients and correlated with clinical laboratory parameters, including autoantibody production. In a mouse model of SjD, IL-9 and Th9-associated cytokines were also elevated, a...

Predicted journal destinations

1
Frontiers in Immunology
140 training papers
Top 0.3% 17.7%
2
JCI Insight
63 training papers
#1 11.8%
3
Arthritis & Rheumatology
21 training papers
Top 0.5% 9.0%
4
Nature Communications
483 training papers
Top 19% 5.9%
5
PLOS ONE
1737 training papers
Top 76% 5.9%
6
The Journal of Immunology
19 training papers
#1 5.0%
7
eLife
262 training papers
Top 10% 4.2%
8
Journal of Clinical Investigation
50 training papers
Top 0.7% 3.9%
9
Annals of the Rheumatic Diseases
23 training papers
Top 0.7% 3.1%
10
Cell Reports Medicine
49 training papers
Top 1.0% 2.8%
11
Science Immunology
15 training papers
Top 0.1% 1.9%
12
Scientific Reports
701 training papers
Top 80% 1.9%
13
Journal of Allergy and Clinical Immunology
15 training papers
Top 1% 1.3%
14
Communications Biology
36 training papers
Top 2% 1.2%
15
iScience
74 training papers
Top 8% 1.2%
16
eBioMedicine
82 training papers
Top 9% 1.0%
17
Cell Reports
25 training papers
Top 1% 0.9%
18
Clinical Infectious Diseases
219 training papers
Top 23% 0.9%
19
Journal of Medical Virology
95 training papers
Top 11% 0.9%
20
Cell Genomics
34 training papers
Top 6% 0.9%
21
Cell
28 training papers
Top 2% 0.9%
22
npj Vaccines
18 training papers
Top 0.6% 0.9%
23
The Journal of Infectious Diseases
137 training papers
Top 17% 0.7%
24
Medicine
29 training papers
Top 6% 0.7%
25
Proceedings of the National Academy of Sciences
100 training papers
Top 20% 0.7%
26
Vaccines
131 training papers
Top 20% 0.5%