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Safety and Immunogenicity of Biological E's 14-valent Pneumococcal Conjugate Vaccine (PNEUBEVAX 14(R)) Administered in a 3p+1 Schedule to Healthy Indian Infants and Toddlers: A Prospective, Multicenter, Active Controlled Phase IV Trial
2025-12-19
infectious diseases
Title + abstract only
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BackgroundBiological Es PNEUBEVAX 14(R) (BE-PCV14) is a WHO-prequalified 14-valent pneumococcal conjugate vaccine that adds emerging serotypes 22F and 33F to PCV13 coverage. We compared the safety and immunogenicity of a 3p+1 infant schedule of BE-PCV14 versus Prevenar 13(R) (PCV13) in Indian infants. MethodsIn this prospective, open-label, multicentre phase IV trial, PCV-naive infants aged 6-8 weeks received three primary doses of BE-PCV14 or PCV13 followed by a booster at 12-15 months. In the...
Predicted journal destinations
1
New England Journal of Medicine
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Clinical Infectious Diseases
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The Journal of Infectious Diseases
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Nature Communications
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The Lancet Infectious Diseases
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Open Forum Infectious Diseases
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JAMA Network Open
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Frontiers in Immunology
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PLOS ONE
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International Journal of Infectious Diseases
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Nature Medicine
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Journal of Infection
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JCI Insight
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eClinicalMedicine
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PLOS Medicine
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eLife
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Journal of Clinical Microbiology
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Science Translational Medicine
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Emerging Infectious Diseases
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eBioMedicine
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Frontiers in Medicine
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BMJ Open
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BMJ
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Journal of Medical Virology
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Scientific Reports
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Eurosurveillance
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