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LysM Receptor Proteins are Required for Ectomycorrhizal Symbiosis in Poplar

Omenge, K.; Werner, S.; Deecke, K.; Irving, T.; Rush, T. A.; Wallner, E.-S.; Keilwagen, J.; Tiwari, M.; Nagalla, S.; Fort, S.; Hallmann, C.; Fladung, M.; Ane, J.-M.

2025-12-17 plant biology
10.64898/2025.12.17.694584 bioRxiv
Show abstract

Successful symbiotic associations often rely on the perception of specific microbial signals by host plants through pattern recognition receptors. LysM receptor-like kinases are key receptors in both rhizobial and arbuscular mycorrhizal symbioses. In this study, we provide the first evidence that such LysM receptor-like kinases also control the establishment of ectomycorrhizal associations in poplar. Using CRISPR/Cas9-mediated genome editing, we knocked out three NFP-like candidate genes in various combinations. We examined their roles in the perception of the ectomycorrhizal fungus Laccaria bicolor, as well as chitin oligomers and lipo-chitooligosaccharides. We demonstrate that all three receptors are necessary for the recognition of symbiosis-related signals, calcium spiking, symbiotic gene expression, and ectomycorrhizal root phenotypes.

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