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Quantitative trait locus mapping of root exudate metabolome in a Solanum lycopersicum Moneymaker x S. pimpinellifolium RIL population and their putative links to rhizosphere microbiome

Kim, B.; Kramer, G.; Leite, M. F. A.; Snoek, B. L.; Zancarini, A.; Bouwmeester, H.

2025-12-17 plant biology
10.64898/2025.12.17.693946 bioRxiv
Show abstract

Crop resilience to abiotic and biotic stresses is vital for sustainable agriculture and global food security. The root exudates (RE)--a complex mixture of metabolites exuded by the plant roots--plays a central role in this resilience by mediating interactions with organisms around the roots, including soil microorganisms. These interactions influence nutrient cycling, the recruitment of beneficial microbes, and ultimately plant health. Although host genotype is known to affect the RE composition, the specific metabolites and underlying genetic mechanisms remain poorly understood. Here, we employed untargeted metabolomics to analyse the tomato RE composition and mapped individual metabolic features to the tomato genome using quantitative trait locus (QTL) analysis in a recombinant inbred line population derived from Solanum lycopersicum and Solanum pimpinellifolium. Our results shed light on the intricate chemical composition of the tomato RE, and reveal domestication-driven shifts in the RE composition and genetic loci associated with the abundance of specific metabolites. Notably, we identify overlap between metabolic and earlier published microbial QTLs, supportive of a link between RE composition and microbiome assembly, and providing a basis for further unravelling of the plant-microbe chemical interaction.

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