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Predicting Methylation-Based Replication Timing from Whole Slide Images
2025-12-19
pathology
Title + abstract only
View on medRxiv
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Replication timing is a costly but powerful tool for characterizing cellular mechanisms that underlie chromatin organization, cancer epigenetics, and genomic instability. Genome-wide replication timing profiles reflect the temporal order of DNA synthesis during S phase and are closely linked to chromatin accessibility, transcriptional activity, and proliferative state. Prior work has demonstrated a robust inverse relationship between replication timing and DNA methylation at the domain scale, en...
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