Back

How Large Language Models Can Affect Clinical Reasoning: A Randomized Clinical Trial

2025-12-18 health systems and quality improvement Title + abstract only
View on medRxiv
Show abstract

ImportanceLLMs have encoded a vast array of medical knowledge and are being integrated into clinical settings as decision-support tools to improve physician performance across various aspects of care. However, evidence of the impact of LLMs on the clinical reasoning of physicians remains limited. ObjectiveTo evaluate the impact of LLM on core aspects of physicians clinical reasoning: diagnostic reasoning, information gathering, and management reasoning in primary care scenarios. Design, Settin...

Predicted journal destinations

1
PLOS ONE
1737 training papers
Top 22% 24.5%
2
BMJ Open
553 training papers
Top 11% 12.1%
3
PLOS Digital Health
88 training papers
Top 2% 8.6%
4
Journal of General Internal Medicine
19 training papers
#1 7.1%
5
BMC Health Services Research
43 training papers
Top 0.6% 6.6%
6
Frontiers in Public Health
135 training papers
Top 7% 4.3%
7
BMC Medical Informatics and Decision Making
36 training papers
Top 4% 4.3%
8
BMJ Open Quality
15 training papers
Top 0.7% 2.1%
9
Journal of Medical Internet Research
81 training papers
Top 8% 2.1%
10
BMC Medical Education
16 training papers
Top 0.8% 2.1%
11
PLOS Global Public Health
287 training papers
Top 22% 1.7%
12
JAMA Network Open
125 training papers
Top 12% 1.7%
13
JMIRx Med
29 training papers
Top 0.7% 1.7%
14
npj Digital Medicine
85 training papers
Top 13% 1.5%
15
Scientific Reports
701 training papers
Top 87% 1.5%
16
BMJ Global Health
95 training papers
Top 12% 1.5%
17
BMC Medical Research Methodology
41 training papers
Top 3% 1.5%
18
Cureus
64 training papers
Top 15% 1.0%
19
JAMIA Open
35 training papers
Top 6% 0.8%
20
International Journal of Environmental Research and Public Health
116 training papers
Top 31% 0.8%
21
Royal Society Open Science
49 training papers
Top 6% 0.8%
22
JMIR Formative Research
31 training papers
Top 6% 0.8%
23
Trials
24 training papers
Top 5% 0.5%
24
British Journal of General Practice
22 training papers
Top 2% 0.5%
25
PLOS Medicine
95 training papers
Top 30% 0.5%