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Whole Genome Sequencing Identifies Crucial Diagnostic Biomarkers and Therapeutic Targets in Premature Coronary Artery Disease in South Asians: A Pilot Study
2025-12-17
genetic and genomic medicine
Title + abstract only
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Background/ObjectivesCoronary artery disease (CAD) remains the leading cause of mortality worldwide, with South Asia bearing a disproportionately high and rising burden, particularly at younger ages. This pilot study aimed to investigate genetic variants associated with premature coronary artery disease (PCAD) using whole genome sequencing (WGS). MethodsWGS was conducted on 12 people (5 PCAD cases, 7 matched controls) to assess feasibility and methodology for future large-scale research. High-q...
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