Back

Improving cross-ancestry generalizability of genetic risk prediction for short stature using a meta-polygenic risk score

2025-12-18 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

BackgroundShort stature (SS) is associated with adverse clinical, psychosocial, and economic outcomes, and early identification of at-risk individuals may enable timely evaluation and intervention. Polygenic risk scores (PRS) for height offer a promising strategy for SS risk stratification. However, substantial ancestry-related differences in PRS distributions and predictive performance limit equitable clinical translation. Improving cross-ancestry generalizability is therefore essential for rel...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 4% 16.7%
2
The American Journal of Human Genetics
77 training papers
Top 1% 11.2%
3
Nature Genetics
72 training papers
Top 1% 8.5%
4
PLOS Genetics
39 training papers
Top 0.2% 5.6%
5
Genetics in Medicine
57 training papers
Top 3% 5.6%
6
Scientific Reports
701 training papers
Top 51% 5.6%
7
Genome Medicine
56 training papers
Top 3% 4.7%
8
Human Genetics and Genomics Advances
39 training papers
Top 1% 3.6%
9
Human Molecular Genetics
28 training papers
Top 0.6% 3.6%
10
Cell Genomics
34 training papers
Top 0.9% 3.6%
11
Communications Biology
36 training papers
Top 0.2% 2.6%
12
PLOS ONE
1737 training papers
Top 94% 1.8%
13
European Journal of Human Genetics
25 training papers
Top 2% 1.8%
14
eLife
262 training papers
Top 25% 1.8%
15
Nature
58 training papers
Top 3% 1.5%
16
Proceedings of the National Academy of Sciences
100 training papers
Top 12% 1.3%
17
Journal of Medical Genetics
22 training papers
Top 3% 1.1%
18
Genes
21 training papers
Top 3% 1.1%
19
Frontiers in Genetics
32 training papers
Top 6% 1.1%
20
Bioinformatics
24 training papers
Top 3% 0.9%
21
Circulation: Genomic and Precision Medicine
30 training papers
Top 7% 0.9%
22
npj Genomic Medicine
18 training papers
Top 4% 0.9%
23
Communications Medicine
63 training papers
Top 9% 0.7%
24
European Journal of Epidemiology
36 training papers
Top 6% 0.7%
25
Nature Medicine
88 training papers
Top 21% 0.7%
26
JAMA Network Open
125 training papers
Top 33% 0.7%