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Optimizing culture-free approaches to recover high quality M. tuberculosis genomic variation

2025-12-18 infectious diseases Title + abstract only
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BackgroundMycobacterium tuberculosis (Mtb) genomic epidemiology often relies on culturing patient sputum, a time and labor-intensive process. Hybrid capture approaches have been successfully used to enrich Mtb DNA from complex clinical samples, yet the accuracy of variant identification from captured samples has not been systematically evaluated. MethodsWe created artificial strain mixtures of two well-characterized Mtb isolates such that the minor strain comprised 0-50% of Mtb DNA and serially...

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