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Multi-ancestry genome-wide association meta-analysis of hepatocellular carcinoma identifies eight novel risk genes including MYC, MAP3K9, DHRS1, and MTTP
2025-12-17
gastroenterology
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Background & AimsHepatocellular carcinoma (HCC) is the third top cause of cancer death globally, often arising on a background of cirrhosis. Here, we aimed to establish novel genetic drivers of HCC across ancestries at a population level through a large meta-analysis of all-cause HCC. Approach & ResultsWe included 15 cohorts comprising 17,329 HCC cases and 2,424,298 controls in this meta-analysis. We found 15 genome-wide significant (P < 5x10-8) germline loci, 6 novel in/near GCKR, MTTP, ADH5, ...
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