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Gene positive vs. gene negative clinical and structural outcomes in hypertrophic cardiomyopathy patients: a meta-analysis and systematic review
2025-12-17
cardiovascular medicine
Title + abstract only
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BackgroundHypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease associated with increased risks of heart failure, sudden cardiac death (SCD), and stroke. Over 1,400 pathogenic variants, primarily in MYH7 and MYBPC3, have been identified, yet the prognostic significance of genetics remains unclear. Recent studies suggest genotype-positive (G+) HCM is linked to earlier diagnosis, greater disease severity, and poorer outcomes, necessitating further research to clarify the r...
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