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A sparse proteomic risk score incorporating plasma MMP12 level improves prediction of abdominal aortic aneurysm

2025-12-18 cardiovascular medicine Title + abstract only
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BackgroundScreening criteria for abdominal aortic aneurysm (AAA) are based on clinical factors, such as age and smoking history, but do not include biological factors that may better reflect disease pathogenesis. ObjectivesWe sought to determine whether a proteomic risk score (ProRS) incorporating plasma protein abundance could improve prediction of AAA. MethodsWe performed a cross-sectional analysis of nearly 37,000 participants in the UK Biobank Pharma Proteomics Project with plasma protein ...

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