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Targeting community-level drivers of antimicrobial resistance in sub-Saharan Africa: the effect of a community-based intervention bundle on household transmission of Extended Spectrum Beta-lactamase-producing E. coli in rural Burkina Faso - a cluster randomised trial

2025-12-16 public and global health Title + abstract only
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BackgroundIn sub-Saharan Africa (sSA), invasive antimicrobial-resistant infections often originate from community-level acquisition. We assessed whether a behavioural intervention bundle targeting sub-optimal antibiotic use and hygiene practices reduced household-level acquisition of extended-spectrum beta-lactamase-producing E. coli (ESBL-E). MethodsWe conducted a cluster-randomised controlled trial in 22 village clusters in Nanoro district, Burkina Faso. We enrolled 12 randomly selected house...

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