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A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder
2025-12-15
psychiatry and clinical psychology
Title + abstract only
View on medRxiv
Show abstract
Obsessive-compulsive disorder (OCD) manifests with diverse symptom constellations that likely arise from dysfunction in partially distinct neural circuits. Deep brain stimulation (DBS), paired with high-resolution connectomics, offers a unique window into these pathways in humans. Here, we analyzed clinical outcomes and stimulation sites from 77 treatment-refractory patients with OCD and 39 with Tourettes syndrome (TS) exhibiting comorbid obsessive-compulsive behaviors (244 electrodes across 15 ...
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