Single-cell transcriptomics reveals a conserved embryonic progenitor in different human cancers
Khozyainova, A.; Subrakova, V.; Menyailo, M.; Zhigalina, D.; Kireeva, T.; Galiakberova, A.; Berestovoy, M.; Kopantseva, E.; Korobeynikova, A.; Dashinimaev, E.; Loos, D.; Tretyakova, M.; Bokova, U.; Skryabin, N.; Denisov, E.
Show abstract
Cellular plasticity, a critical feature of embryonic development, is often reactivated in cancer, enabling tumor cells to acquire stem-like properties and facilitate uncontrolled growth. This study compares cellular plasticity in cancer and early human development by integrating single-cell data from three cancers and embryoid bodies. The analysis identifies a shared, highly proliferative progenitor-like state, driven by an E2F-TFDP transcriptional axis and enriched in key cell-cycle regulators UBE2C, TOP2A, BIRC5, and NUSAP1. Functionally linked to cell-cycle progression and DNA repair, this state acts as a lineage hub within tumors. Spatial transcriptomics revealed that this state is enriched in lung adenocarcinoma and in lung tissue with basal cell hyperplasia, a potential precursor to squamous cell carcinoma. Validation across eight cancer types demonstrates a prevalence of this program in tumors versus normal cells. Collectively, these findings define a conserved mechanism of tumor plasticity with potential for early detection and targeted therapy. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=150 SRC="FIGDIR/small/693590v2_ufig1.gif" ALT="Figure 1"> View larger version (49K): org.highwire.dtl.DTLVardef@d8d8fborg.highwire.dtl.DTLVardef@8d5cb7org.highwire.dtl.DTLVardef@c1f3b0org.highwire.dtl.DTLVardef@165af61_HPS_FORMAT_FIGEXP M_FIG C_FIG
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment 96%
- Histone H3.3 lysine 9 and 27 control repressive chromatin states at cryptic cis-regulatory elements and bivalent promoters in mouse embryonic stem cells 95%
- Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma 95%
Similar papers in this journal
Similar papers in this journal
- Single cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers 96%
- An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs. 95%
- Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs 95%
Similar papers in this journal
- Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition 96%
- Retroelement co-option disrupts the cancer transcriptional programme 95%
- Evaluating the transcriptional fidelity of cancer models 95%
Similar papers in this journal
- Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer 95%
- Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals an invasive tumor vasculature phenotype 95%
- Integrated Molecular Characterisation of the MAPK Pathways in Human Cancers 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.