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Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression

2025-12-12 neurology Title + abstract only
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Alzheimers disease (AD) arises from synergistic interactions between amyloid-{beta}, tau, and neurodegeneration, yet it remains unclear how these mechanisms reshape the hierarchical organization of large-scale brain dynamics. Here, we quantified directed causal interactions across 134 participants spanning the AD continuum, comprising 46 amyloid-negative healthy controls (HC-), 36 amyloid-positive healthy controls (HC+), 31 amyloid-positive individuals with mild cognitive impairment (MCI+), and ...

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