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HIV and antiretroviral treatment as drivers of rifampicin-resistant tuberculosis in South Africa: insights from mathematical modelling
2025-12-12
infectious diseases
Title + abstract only
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BackgroundHigh levels of multidrug and rifampicin resistant tuberculosis (MDR/RR-TB) are a global concern, although they have declined over the last decade. TB patients are at increased risk of acquired rifampicin resistance if they have HIV coinfection, especially at low CD4 counts, but this dynamic has not previously been modelled. MethodsWe extended a previously-developed model that simulates HIV and TB in South African adults, to include the acquisition and transmission of rifampicin resist...
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