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Skin Seed Amplification Assay differentiates Multiple System Atrophy from Parkinson's Disease

2025-12-15 neurology Title + abstract only
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BackgroundMisdiagnoses of multiple system atrophy (MSA) and Parkinsons disease (PD) remain common due to overlapping clinical features. ObjectiveTo develop and assess a skin -synuclein seed amplification assay (Syn-SAA) for detecting pathological -synuclein and distinguishing MSA from PD. MethodsIn this blinded, cross-sectional study conducted across two laboratories, 308 skin biopsies from 117 participants were analyzed using a standardized Syn-SAA protocol. The cohort included 42 PD, 31 MSA,...

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