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Leveraging blood RNA expression to understand Parkinson's disease heterogeneity and progression

2025-12-12 neurology Title + abstract only
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Parkinsons disease (PD) exhibits substantial clinical and molecular heterogeneity, driven in part by mutations in SNCA, GBA1 and LRRK2 genes. Understanding how these genetic subtypes differ in progression and peripheral transcriptomic profiles may inform personalized prognostic and therapeutic strategies. In this study, we aim to compare disease progression trajectories and blood-based gene expression patterns among SNCA-positive (SNCA+), GBA-positive (GBA+) and LRRK2-positive (LRRK2+), and spor...

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