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Evolutionary divergence and expression of differential HLA alleles between donor and recipient influence acute GVHD onset after allogenetic HSCT
2025-12-12
hematology
Title + abstract only
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Acute graft-versus-host disease (aGVHD) remains a major complication after hematopoietic stem cell transplantation (HSCT), especially given haploidentical HSCT is now Chinas primary method, yet this context lacks reliable predictors. aGVHD initiation, involving donor T cell activation by recipient conventional dendritic cells (cDCs), depends on donor-recipient HLA disparity and its expression. We therefore developed the donor and recipient-specific HLA evolutionary divergence (DRs_HED) algorithm...
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