Back

A Novel Linear B-spline Mixed Model for Repeated Measures (LB-MMRM) for Alzheimer's Disease Clinical Study Data

2025-12-11 neurology Title + abstract only
View on medRxiv
Show abstract

Mixed Models for Repeated Measures (MMRM) are widely used in neurological clinical trials, including Alzheimers disease studies, due to their robust statistical properties and regulatory acceptance. However, traditional MMRM treats time as a categorical variable, limiting its ability to incorporate unscheduled visits, harmonize trials with different visit schedules, or handle densely collected data from digital health technologies. To address these limitations, we propose a Linear B-Spline-based...

Predicted journal destinations

1
PLOS ONE
1737 training papers
Top 62% 8.8%
2
Alzheimer's & Dementia
84 training papers
Top 2% 7.6%
3
npj Digital Medicine
85 training papers
Top 3% 6.3%
4
Scientific Reports
701 training papers
Top 40% 6.3%
5
BMC Medical Research Methodology
41 training papers
Top 0.1% 5.8%
6
Frontiers in Neurology
74 training papers
Top 5% 4.9%
7
Brain Communications
79 training papers
Top 5% 4.1%
8
Journal of Alzheimer's Disease
31 training papers
Top 2% 3.8%
9
Alzheimer's Research & Therapy
31 training papers
Top 2% 3.8%
10
Nature Communications
483 training papers
Top 33% 2.7%
11
Brain
69 training papers
Top 6% 1.9%
12
Human Brain Mapping
53 training papers
Top 4% 1.9%
13
Journal of Alzheimer’s Disease
23 training papers
Top 1% 1.9%
14
Annals of Neurology
43 training papers
Top 4% 1.9%
15
Neurology
38 training papers
Top 5% 1.9%
16
npj Parkinson's Disease
35 training papers
Top 2% 1.9%
17
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
28 training papers
Top 2% 1.9%
18
BMJ Open
553 training papers
Top 50% 1.9%
19
Epilepsia
27 training papers
Top 2% 1.5%
20
Journal of Neurology, Neurosurgery & Psychiatry
26 training papers
Top 5% 1.3%
21
Movement Disorders
49 training papers
Top 5% 1.3%
22
Nature Medicine
88 training papers
Top 10% 1.1%
23
European Journal of Neurology
20 training papers
Top 4% 1.1%
24
eLife
262 training papers
Top 40% 1.1%
25
Parkinsonism & Related Disorders
16 training papers
Top 3% 1.1%
26
NeuroImage
36 training papers
Top 5% 1.0%
27
Brain Stimulation
27 training papers
Top 4% 0.9%
28
Neurobiology of Aging
29 training papers
Top 5% 0.9%
29
PLOS Digital Health
88 training papers
Top 16% 0.9%
30
NeuroImage: Clinical
77 training papers
Top 11% 0.9%