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A randomized, double-blind assessment of the effects of vortioxetine on functional connectivity in mild cognitive impairment
2025-12-11
psychiatry and clinical psychology
Title + abstract only
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Vortioxetine has been reported to alleviate cognitive deficits in patients with depression, accompanied by changes in functional connectivity (FC). An open-label study suggested potential benefits of vortioxetine in patients with mild cognitive impairment (MCI), a condition also characterized by both cognitive and FC alterations. However, controlled studies are required to rule out nonspecific treatment effects and to determine whether FC changes are generalizable to this population. To address...
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