Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model
Kaiser, F. K.; Gallogly, S.; Mukesh, R.; Ochwoto, M.; Yinda, K. C.; van Tol, S.; Schulz, J.; Hawes, K.; Bulloch, B.; McBain, A.; Bushmaker, T.; Okumura, A.; Prado-Smith, J.; Smith, B.; Rosenke, K.; Saturday, G.; Munster, V.
Show abstract
We compared clinical disease, virus shedding and dissemination following genital MPXV clade Ia and Ib infections in Mastomys natalensis. MPXV clade Ib resulted in a milder clinical disease but a similar shedding profile to clade Ia. These findings indicate a prolonged pre-symptomatic or prodromal shedding period in clade Ib infections.
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