Artificial hibernation uncovers distinct synaptic engram architecture for memory retention
Lin, Y.-J.; Takahashi-Nakazato, A.; Tsutsumi, K.; Takahashi, T.; Mercier, D.; Ashitomi, H.; Chiang, M.-C.; Haberl, M.; Uytiepo, M.; Maximov, A.; Makino, Y.; Nemoto, T.; Enoki, R.; Hirano, A.; Soga, K.; Looprasertkul, S.; Ohno, N.; Kubota, Y.; Sakurai, T.; Tanaka, K. Z.
Show abstract
The memory trace at the neuronal and synaptic levels remains controversial. Stable, larger spines are thought to support memory, but the high turnover of dendritic spines and the drifting of neuronal representations following memory formation suggest alternative possibilities. To elucidate a structural trace underlying memory retention, we utilize a mouse model of artificial hibernation. During hibernation, hippocampal neurons exhibited a substantial reduction in their activity and an extensive elimination of dendritic spines and synapses. Despite these changes, their memory and associated hippocampal neuronal representations are intact after arousal. We find that a subset of spines is maintained during hibernation. These spatially clustered engram-engram synapses are exclusively protected from elimination and characterized by synaptic contacts with multi-synaptic boutons. These findings suggest that synaptic engram architecture, rather than larger spines per se, is resilient to network remodeling and underlies long-term memory retention.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development 96%
- A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory 96%
- LTP induction boosts glutamate spillover by driving withdrawal of astroglia 96%
Similar papers in this journal
- Theta-band phase locking during encoding leads to coordinated entorhinal-hippocampal replay 96%
- Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo. 95%
- Activity-dependent nucleation of dynamic microtubules at presynaptic boutons is required for neurotransmission 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.