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Transcriptome-wide association implicates HTRA1-AS1 in age-related macular degeneration risk

2025-12-07 genetic and genomic medicine Title + abstract only
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Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment and legal blindness that has significant genetic risk factors, including genetic variation within a locus on chromosome 10 encompassing several extensively studied protein-coding genes (ARMS2, HTRA1 and PLEKHA1). Here, through transcriptome-wide association and fine-mapping approaches that integrate newly available high coverage transcriptome datasets for the human eye, we provide robust statistical assoc...

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