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Spatial, Temporal, and Molecular Heterogeneity of ADC targets in High-Grade Serous Ovarian Carcinoma
2025-12-05
oncology
Title + abstract only
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BackgroundAntibody-drug conjugates (ADCs) represent a promising therapeutic approach for high-grade serous ovarian carcinoma (HGSOC). Patient selection for ADC therapy depends on tumor target expression, making it essential to characterize molecular, spatial, and temporal heterogeneity. MethodsWe analyzed two HGSOC tissue microarray cohorts: 100 genomically profiled primaries (1,565 cores) and 64 matched cases with paired primary (P), primary disseminated (PD), and recurrent (R) samples (2,395 ...
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