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Linezolid population pharmacokinetics in rifampicin-resistant tuberculosis patients and interpretation challenges of the probability of target attainment

2025-12-05 pharmacology and therapeutics Title + abstract only
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Linezolid is a key component of the BPaLM regimen (bedaquiline, pretomanid, linezolid, and moxifloxacin), the recommended treatment for rifampicin-resistant tuberculosis (RR-TB). However, its optimal dosing and duration remain uncertain. To support dose optimization and efficacy interpretation, we developed a population pharmacokinetic (PK) model of linezolid and evaluated exposure and probability of target attainment (PTA). Ninety-four RR-TB patients received linezolid 600 mg daily for 16 weeks...

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