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Characterization of the First Complete Genome Sequence of Yellow Fever Virus (YFV) isolate in Sierra Leone: Implications for Public Health
2025-12-06
public and global health
Title + abstract only
View on medRxiv
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Yellow fever virus (YFV), a mosquito-borne flavivirus that causes severe hemorrhagic disease, is endemic in parts of South America and Africa, yet genomic data from Sierra Leone is lacking despite ongoing surveillance. Using hybrid-capture metagenomic sequencing, we generated a complete 10,611-bp YFV genome (98% coverage) from an adult male patient who reported to the Kailahun Government Hospital with fever and muscle pain. Phylogenetic analysis assigned the genome to West African Clade V via th...
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