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Improving Assessment of Vaccine Effectiveness by Coupling Test-Negative Design Studies with Survival Models

2025-12-04 epidemiology Title + abstract only
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The test-negative design (TND) has become a widely used observational study design for evaluating vaccine effectiveness, especially during the COVID-19 pandemic. Traditionally, TND has been viewed as a variant of the case-control study and largely limited to use with logistic regression models. In this paper, we first establish that TND can be framed as a special case of a cohort study, thereby opening the door to a wider range of analytical approaches. We then introduce the Prentice, Williams, ...

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