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Single-Cell Mendelian Randomization Identifies Cell-Type Specific Genetic Drivers of Lung Cancer Subtypes

2025-12-02 genetic and genomic medicine Title + abstract only
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BackgroundGenome-wide association studies (GWAS) have identified many loci linked to lung cancer, but connecting these loci to causal genes and relevant cell types remains difficult. Traditional Mendelian randomization (MR) using bulk tissue eQTLs averages signals across diverse cells, masking cell-specific effects. Here, we apply single-cell eQTL based MR to infer causal relationships at immune-cell resolution, revealing mechanisms not detectable in bulk analyses. MethodsWe conducted single-ce...

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